reprogramming

Though it is merely a metaphor, the developmental landscape vividly describes the autonomous hierarchical bifurcation of cellular differentiation and implies the possibility of conversions between different cell types. Therefore, recently it is used extensively as a universal framework to explain both of the development and reprogramming.

虽然它只是一个隐喻，但其形象地描述了细胞的自发的层次分叉过程并隐含了细胞类型之间转换的可能性，从而作为一个整体框架最近被广泛应用来解释细胞发育和重编程。

IPSCs obtained from embryonic stem cells in the inner cell mass of blastocysts, the nuclear transfered embryonic stem cells and the exogenous transcription factor transferred somatic cells were used to conduct the somatic cell reprogramming research.

通常用来源于囊胚期胚胎的内细胞团的胚胎干细胞、通过核移植得到的胚胎干细胞以及在成体细胞中转入外源转录因子得到的iPSCs，进行体细胞重编程研究。

It indicates that female fetal fibroblasts are more suitable as donor cells, while th change in the methylation level is not conducive to improve nuclear reprogramming.

这表明雌性胎儿成纤维细胞更适合作为体细胞核移植的供体细胞，而改变其甲基化水平不利于体细胞重编程。