metastatic

Methods Twenty one patients ( male 16, female 5) underwent transsplenic CO2 digital substraction splenoportography with 26 G ultrafine-needle under ultrasound or fluoroscopic guidance. Among them, 15 patients with primary hepatic carcinoma, 6 with hepatic metastatic cancer.

方法21例患者，原发性肝癌15例，转移性肝癌6例。以26G超细针在B超引导或透视定位下经皮穿刺至脾内，行CO2鄄DSA。

131 I-labeled anti-normal mice IgG was injected through tail vein after the liver metastatic model was estabished as a control group.

并以模型建立后经尾静脉注射131I标记的正常小鼠IgG作为对照组。

These results demonstrate that overexpression of COX-2 can lead to phenotypic changes that alter the metastatic and angiogenic potential of TCC cancer cells.

结论：COX-2的过表达能促进EJ肿瘤细胞侵袭转移和血管生成能力表型方面的改变，即COX-2能促进肿瘤细胞体外侵袭能力的增强和促血管生成能力的增强。