sirnas

CONCLUSIONS: Sequence specific siRNAs targeting HER-2 is capable of suppressing HER-2 expression, slowing cell proliferation and inducing cell apoptosis. HER-2 siRNA may be a new tool for molecular target therapy for ovarian carcinoma.

结论体外转录合成的HER-2siRNA能特异抑制HER-2基因表达，抑制细胞增殖，诱导细胞凋亡，siRNA有望成为卵巢癌分子靶向治疗的一个新工具。

RNA interference ( RNAi), an evolutionary highly conserved process of posttranscriptional gene silencing, can be triggered by small interfering RNAs ( siRNAs) that mediate sequence-specific mRNA degradation.

RNA干扰（RNAi）是指生物体内由小干扰RNA（siRNAs）介导的具有高度特异性，只降解与之序列相应的单个内源基因mRNA的，在进化上高度保守的转录后基因沉默现象。

Recently, short interfering RNAs ( siRNAs) has been successfully used in the mammalian cell systems. Advances in the research and applications of gene-silencing technologies induced by siRNAs will be reviewed here.

近年来，短链RNA干扰（siRNAs）已成功地应用于哺乳动物中，该文就其介导的基因沉默技术和相关应用的研究进展进行综述。