nitro-助记

Study of single factor ( carbon resource and nitro resource) and orthogonal test discovered that the fermentation medium containing 2% corn powder, 3% bean cake powder and 3% bran is good for neutral proteinase ( NPR) production.

单因素碳、氮源及正交试验发现以2%玉米粉、3%豆粕粉作为碳、氮源并辅以3%麸皮作为生长因子产酶最好。

Scheme 1 started from o-nitro ethylbenzene. It was actually a model study of Bamberger reaction to test the method for an extended Bamberger reaction to give 5-methoxy substituent.

路线一是从邻硝基乙苯出发、探索Bamberger反应的模型实验。

The intermediates 3, nitro compounds, were reduced into corresponding intermediate amido compounds 4 by Pd/ C catalysis-hydrogenation. The target compounds 5 ware obtained by the reaction phenylisothiocyanate with the intermediate amido compounds 4, which do not have been separated.

利用Pd/C催化加氢的方法，将中间体硝基化合物3还原成相应的中间体氨基化合物4，制得的中间体氨基化合物，无需进一步纯化即可直接与异硫氰酸苯酯反应，得到目标产物5。