grignard

Preparation of highly reactive solvated metal magnesium atoms via metal vapor synthesis and preparation of Grignard reagent

金属蒸气合成法制备高活性的溶剂化金属镁原子及格氏试剂

△~ 6-6-methyl spirolactone(ⅷ) was synthesized from epoxide(ⅱ) through the following series of reaction, viz, Grignard synthesis with the introduction of 6-methyl and side chain carboxyl groups simultaneously, followed by catalytic hydrogenation, chromic acid oxidation, dehydration and dehydrogenation.

△~6-6-甲基螺甾内酯（Ⅷ）可从环氧化合物（Ⅱ）经Grignard试剂一步加入6-甲基及侧链羧基，继用常法氢化、氧化、脱水、脱氢等步骤合成。

Two synthetic methods of organosilicon compounds were adapted. Comparing the merits and demerits of the two methods, we found that it is convenient to use Grignard reagent in the reaction in almost same yield.

采用两种方法对有机硅化合物的合成进行了初步的探索，并比较了两种合成方法的优缺点，发现在产率大致相同的条件下，格式试剂法的后处理比较方便。