dnmts的翻译

Objective To investigate the correlation between aberrant methylation status of ras association domain family 1A ( RASSF1A), transcriptional levels of DNA methyltransferases ( DNMTs) and hepatitis B virus ( HBV) infection in patients with hepatocellular carcinoma ( HCC).

目的探讨原发性肝癌ras相关结构域家族1A（ras association domain family1A，RASSF1A）异常甲基化与肿瘤组织中DNA甲基转移酶（DNA methyltransferases，DNMTs）转录水平变化及HBV感染的关系。

In recent years with the development of epigenetics, DNA methyltransferases ( DNMTs) inhibitors have been successfully approved in the clinical treatment of hematological malignancies, and they have began clinical trials in various adult cancers.

近年来随着表观遗传学的发展，DNMTs抑制剂已成功获得批准应用于血液系统疾病的临床治疗，在其他成人多种肿瘤中也开始了临床试验。

To determine whether DNMTs inhibitors are applicable for neuroblastoma, or combination with traditional radiotherapy and chemotherapy to improve the efficacy, we must understand the exact function of DNMTs in neuroblastoma firstly.

然而其能否应用于儿童神经母细胞瘤的治疗，或与传统放化疗联合应用改善疗效，我们就应首先了解DNMTs蛋白的表达情况。